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Old 26th October 2009, 08:53 PM   #41
skeptigirl
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Quote:
In the flu-vaccine world, Jefferson’s call for placebo-controlled studies is considered so radical that even some of his fellow skeptics oppose it.
I find this statement totally false. Many placebo controlled flu vaccine studies have been done.

The Efficacy of Influenza Vaccination in Elderly Individuals - A Randomized Double-blind Placebo-Controlled Trial
Quote:
Conclusion.
—In the elderly, influenza vaccination may halve the incidence of serological and clinical influenza
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Old 26th October 2009, 10:06 PM   #42
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Originally Posted by skeptigirl View Post
You don't get a W age curve by simply increasing the numbers of those infected.
That is an assertion. As I've said, it may even be correct. But I don't believe you'll be able to support it with evidence -- other than with the very same epidemiological evidence which inspires you to assert it.

It's called "affirming the consequent". In this instance, it looks like this:

If the virus is special, the age distribution curve will be different.
The age distribution curve is different.
Therefore, the virus is special.
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Old 26th October 2009, 10:14 PM   #43
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Originally Posted by skeptigirl View Post
I find this statement totally false. Many placebo controlled flu vaccine studies have been done.

The Efficacy of Influenza Vaccination in Elderly Individuals - A Randomized Double-blind Placebo-Controlled Trial

That's a pretty good study. If that result is typical from these kinds of studies, maybe articles like the one I linked to are the result of someone, somewhere down the line, mistaking a 50% reduction in infection for a 50% reduction in mortality.
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Old 26th October 2009, 11:11 PM   #44
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Old 26th October 2009, 11:16 PM   #45
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Old 26th October 2009, 11:58 PM   #46
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To me, it seems very straightforward.
Somebody please feel free to correct me if my facts are wrong here, but over 5000 people have died so far of this strain of H1N1, and zero have died of the vaccine AFAIK, and zero have had negative reactions attributable to the vaccine AFAIK.

Not getting the vaccine is like playing Russian roulette.
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Old 27th October 2009, 02:26 AM   #47
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Originally Posted by Dymanic View Post
That is an assertion. As I've said, it may even be correct. But I don't believe you'll be able to support it with evidence -- other than with the very same epidemiological evidence which inspires you to assert it.

It's called "affirming the consequent". In this instance, it looks like this:

If the virus is special, the age distribution curve will be different.
The age distribution curve is different.
Therefore, the virus is special.
Apparently you are not reading the current epidemiology of this flu strain. I don't have time to do the lit search for you. How about you show us the lit supporting your false assertion here instead?
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Old 27th October 2009, 02:31 AM   #48
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Originally Posted by Brian-M View Post
That's a pretty good study. If that result is typical from these kinds of studies, maybe articles like the one I linked to are the result of someone, somewhere down the line, mistaking a 50% reduction in infection for a 50% reduction in mortality.
There are a couple confounding studies like the ones mentioned here which failed to show a drop in the overall death rate to go along with increased vaccine use. This is not new news. It also is not evidence flu vaccine doesn't work. It is evidence something else is going on.

More than sufficient studies have confirmed flu vaccine is effective. My hypothesis is, either the contradicting outcomes are from flawed studies, or if flu extends people's lives, it may not extend them more than a few months in the very oldest populations. I don't think the death rate studies have been well explained. However, they are contradicted by many other studies which support the effectiveness of flu vaccine.
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Old 27th October 2009, 02:34 AM   #49
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Oops, my wife got her information from the respected Robert Koch Institute.
They (allegedly) say that the vaccine has not been sufficiently tested, to rule out adverse health effects.

The site is German, so I'll have to ask my wife to point out the relevant bits. I really cannot plow through that much medical jargon in Hun. (sorry honey).

Hopefully I'll have time to look it up tomorrow.

The incident with the paralysed child was hearsay.
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Old 27th October 2009, 03:38 AM   #50
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I've been vaccinated, hubby is going on Monday.

For me it was a no brainer, I work in a games store in a mall, and the mall has a doctors surgery. The first thing a parent does after visiting the surgery with little Johnny and discovering little Johnny is sick and is going to be off school for 2 weeks is drag him coughing and sneezing into my store to get something to entertain him.

I've already had whooping cough as a result (didn't realise the childhood vaccine wore off), didn't really fancy H1N1.

Parents around here are mainly anti-vaxxers, one of the local areas was recently in the news for the major outbreak in a school of whooping cough, so anything I can do for self preservation I will.
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Old 27th October 2009, 03:51 AM   #51
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Originally Posted by softstuff View Post

Parents around here are mainly anti-vaxxers


That is disturbing. What is wrong with modern societies to have such strong anti-rational trends?
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Old 27th October 2009, 04:55 AM   #52
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Originally Posted by Eddie Dane View Post


That is disturbing. What is wrong with modern societies to have such strong anti-rational trends?
I live in a lovely area, but it's full of woo. Everything from organic coffee shops to crystal stores and tarot readers. Still, it makes the queue at the doctors surgery pretty short and you never have to wait long for decent books at the library
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Old 27th October 2009, 05:01 AM   #53
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Originally Posted by Brian-M
I usually don't put too much faith in sensationalistic articles I stumble across on the internet, and I'm not against vaccination in general, but this does raise a question in my mind.
Why? Do you think relevant information is not accessible to health care providers and other experts, or that they are not able to reason as effectively from that information as a couple of reporters?

Quote:
How effective are flu shots at reducing the effects of mortality of the seasonal flu? Even the links you provide admit the seasonal flu shots have flaws...

Quote:
In any case, as Mark Crislip pointed out, vaccines for seasonal flu are suboptimal for a variety of reasons.
Quote:
Also, the elderly, the ones most likely to die of complications after the flu, tend not to develop as robust an immune response to the vaccine.
This provides support for the idea that immunizing those who may pass on influenza to the frail elderly might be more effective than focussing on the frail elderly.

For example:

http://www.thelancet.com/journals/la..._eventId=login

Linda
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Old 27th October 2009, 06:31 AM   #54
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Originally Posted by Yeggster View Post
What?
Nothing! Here's your ninepence
I'm getting better.
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Old 27th October 2009, 06:58 AM   #55
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Originally Posted by skeptigirl View Post
Apparently you are not reading the current epidemiology of this flu strain.
Apparently you are not reading what I've posted.

Quote:
How about you show us the lit supporting your false assertion here instead?
Which assertion was that?
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Old 27th October 2009, 07:10 AM   #56
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Originally Posted by fls View Post
I think that you'd be better off not getting information from people who have no expertise and whose motivation is to sensationalize, rather than inform.

http://scienceblogs.com/insolence/20...uenza.php#more
http://www.sciencebasedmedicine.org/?p=2258

Linda
What are those two ad hominem pieces supposed to prove, other than the authors couldn't (or didn't want to) be bothered with addressing the points Jefferson et al. have raised?

Last time I looked at the evidence it suggested to me:

i) Seasonal flu vaccination is probably not much use in the elderly...
ii) ...but more effective in the young and middle aged.
iii) (ii) can provide indirect benefits to the elderly if enough people are vaccinated.
iv) Monovalent flu vaccines developed for pandemic flu (such as the current vaccines for H1N1) are generally more effective than the trivalent vaccines are for seasonal flu.
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Old 27th October 2009, 07:28 AM   #57
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Originally Posted by Ivor the Engineer View Post
What are those two ad hominem pieces supposed to prove, other than the authors couldn't (or didn't want to) be bothered with addressing the points Jefferson et al. have raised?

Last time I looked at the evidence it suggested to me:

i) Seasonal flu vaccination is probably not much use in the elderly...
ii) ...but more effective in the young and middle aged.
iii) (ii) can provide indirect benefits to the elderly if enough people are vaccinated.
iv) Monovalent flu vaccines developed for pandemic flu (such as the current vaccines for H1N1) are generally more effective than the trivalent vaccines are for seasonal flu.
If you think those were the main take-away points in The Atlantic article, then kudos for you.

Linda
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Old 27th October 2009, 11:10 AM   #58
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Originally Posted by Brian-M View Post
I usually don't put too much faith in sensationalistic articles I stumble across on the internet, and I'm not against vaccination in general, but this does raise a question in my mind.

How effective are flu shots at reducing the effects of mortality of the seasonal flu? Even the links you provide admit the seasonal flu shots have flaws...
See also http://scienceblogs.com/effectmeasur...the_atlant.php
and
http://scienceblogs.com/effectmeasur..._sur_rebut.php

and http://www.sciencebasedmedicine.org/?p=2040
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Old 27th October 2009, 11:43 AM   #59
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I'm 37, and have pretty bad asthma / bronchial stuff from too much smoking (yes, I know). If I were to get swine flu, it would not be good news. At least, not for me.

I'm in a sort of medium-risk group - once the elderly and seriously ill have been vaccinated, we wheezers are next in line. I'm almost certainly going to get it, but I can't help feeling somewhat dubious for some reason. I'm completely pro-vaccination, never had the slightest sympathy for woo, and yet I'm ever-so-slightly nervous about getting this shot. I don't quite understand it. Maybe my very nasty reaction to a controversial drug, a few years ago, has left me overly cautious.

Or maybe FUD is an airborne disease.
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Old 27th October 2009, 11:50 AM   #60
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Originally Posted by BenBurch View Post
I'm getting better.
No you're NOT, you'll be stone dead in a moment.
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Old 27th October 2009, 12:33 PM   #61
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Originally Posted by Eddie Dane View Post
Oops, my wife got her information from the respected Robert Koch Institute.
They (allegedly) say that the vaccine has not been sufficiently tested, to rule out adverse health effects.

The site is German, so I'll have to ask my wife to point out the relevant bits. I really cannot plow through that much medical jargon in Hun. (sorry honey).

Hopefully I'll have time to look it up tomorrow.

The incident with the paralysed child was hearsay.
So riddle me this. What does the Koch Institute think of the adverse health effects of the more than sufficiently observed actual H1N1 flu infection?
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Old 27th October 2009, 12:39 PM   #62
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Originally Posted by Dymanic View Post
Apparently you are not reading what I've posted.
So I should buy your unsupported hypothesis rather than the actual epidemiology reports I've read written by actual researchers?

There are several out there. The US's CDC has one. The EU surveillance organization put one out. And someone wrote up the characteristics of the first Mexican fatalities and hospitalized patients, can't remember who as that one was many months ago.

I'm just not going to find links for you on these three papers, I don't have time.

You are speculating. These researchers reported on the actual epidemiology of the hospitalized and fatal cases.




Originally Posted by Dymanic View Post
Which assertion was that?
Your assertion that we are merely seeing widespread disease with the same demographics expected with increased numbers of cases rather than something specifically different in the virulence of this flu strain.
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Old 27th October 2009, 01:12 PM   #63
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Originally Posted by Yeggster View Post
No you're NOT, you'll be stone dead in a moment.
I don't want to go on the cart!
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Old 27th October 2009, 01:12 PM   #64
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Originally Posted by skeptigirl View Post
So I should buy your unsupported hypothesis rather than the actual epidemiology reports I've read written by actual researchers?
Your continued pointing to the epidemiology indicates that you really aren't getting what I'm saying here. When you have time, I suggest you re-read my posts more carefully.

Quote:
There are several out there. The US's CDC has one. The EU surveillance organization put one out. And someone wrote up the characteristics of the first Mexican fatalities and hospitalized patients, can't remember who as that one was many months ago. I'm just not going to find links for you on these three papers, I don't have time.
Don't bother with the link dump. I've already read them anyway. You're trying to use epidemiological data to explain a trend in epidemiological data. It's tautological. Your assumptions are apparently completely transparent to you.

Quote:
You are speculating.
Interesting comment considering that that's exactly what I see you doing. What's worse is that you don't even seem to realize that it's speculation.

Quote:
Your assertion that we are merely seeing widespread disease with the same demographics expected with increased numbers of cases rather than something specifically different in the virulence of this flu strain.
I will concede that in the interest of better conveying the fact that I was not making an "assertion", I might have chosen my words more carefully; in the statement "There's nothing particularly unique about the virus itself", the qualifier, "particularly" was not strong enough.

As I've already acknowledged (twice), it might be reasonably argued that something we might call "different virulence" is the best explanation for the patterns we're seeing in the epidemiological data (you can't really argue for "greater virulence", since we aren't seeing that, but I'd entertain the idea of different virulence). But you seem to want to treat that as the only possible explanation, and it certainly is not. I don't agree that it is even the best explanation -- just that it is not unreasonable. You seem to want to insist on viewing "virulence" as solely a property of the virus. I don't agree with that. You also seem to want to insist that trends in the epidemiological data may be treated as if they can stand alone as evidence for a given explanation of those very trends -- and I REALLY don't agree with that.

Do you feel that you have a firm grasp of the formal logical fallacy referred to as "affirming the consequent"?
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Old 27th October 2009, 01:24 PM   #65
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Originally Posted by MattusMaximus View Post
It's a no brainer: yes, vaccinate your kids. Then get yourself vaccinated, if possible.
That definitely is a "NO BRAIN-er"

H1N1 vaccine contains thimerosal which is well documented has being toxic and hazardous, especially to children.

Dr. Tom Jefferson, head of the Vaccines Field at the Cochrane Collaboration, a highly respected international network of researchers who appraise medical evidence says;

"Tamiflu has not been proven to have a positive impact on the potential consequences, such as hospitalizations, mortality, or economic impact of seasonal, avian or pandemic influenza."

This same statement is on the Tamiflu website also.

Also this statement is from The Atlantic

"We have built huge, population based policies on the flimsiest of scientific evidence. The most unethical thing to do is to carry on business as usual."

Dr. Jefferson's requests for placebo-controlled studies on the effectiveness of flu vaccine have been called "radical" by the CDC.

When did it become radical to test effectiveness of a drug?


The CDC says that H1N1 is just as safe and effective as seasonal flu shot, so;

Lancet study finds vaccine not effective for the elderly.
http://www.nytimes.com/2008/09/02/health/02flu.html

The Centers for Disease Control (CDC) is looking at whether or not the flu vaccine is effective. Preliminary results indicate you'll get just as sick (with colds, flu, flu-like illnesses) if you got the vaccine than if you didn't.
http://chemistry.about.com/cs/howthi.../aa011604a.htm

Dr. Lawrence B. Palevsky, a pediatrician with the Northport (N.Y.) Wellness Center and president and co-founder of the Holistic Pediatric Association

"The dogmatic view that vaccines are safe and effective is being met with a considerable amount of attention, which is warranted and needed,"

Person experience, I have never received a flu shot in my life and I only had the flu once in my 35 years.
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Old 27th October 2009, 01:34 PM   #66
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Originally Posted by Without Rights View Post
H1N1 vaccine contains thimerosal which is well documented has being toxic and hazardous, especially to children.
As about a dozen posters are about to inform you, those "hazards" are not as well supported by evidence as you may suppose, but those who are concerned about this should have no great difficulty obtaining thimerosal-free vaccine (the single-dose vials don't have it) -- that is, no more difficulty than with finding novel H1N1 vaccine at all, which is still a bit of a trick in most places.
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Old 27th October 2009, 01:42 PM   #67
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WR, nonsense like that is KILLING people. How can you be so smug and irresponsible?
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Old 27th October 2009, 02:00 PM   #68
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Originally Posted by Puppycow View Post
To me, it seems very straightforward.
Somebody please feel free to correct me if my facts are wrong here, but over 5000 people have died so far of this strain of H1N1, and zero have died of the vaccine AFAIK, and zero have had negative reactions attributable to the vaccine AFAIK.

Not getting the vaccine is like playing Russian roulette.

Russian roulette? That is the overstatement of the year. 5000 deaths worldwide in a population of 6.7 billion or .0000007462%

Zero negative reactions is not correct,

7 health care workers reported vomiting, loss of consciousness, and other minor effects.

Hospitals reported that 25 patients were exhibiting adverse effects from the new vaccine, including two serious cases.

The Center for Disease Control and Prevention (CDC) has officially stated that there will be as many as 30,000 serious, potentially lethal adverse reactions to the novel H1N1 vaccine, or 1 out of 100,000.

Also, as of today, the CDC has not started tracking adverse reactions, although the plan is now in place.
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Old 27th October 2009, 02:04 PM   #69
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Originally Posted by Dymanic View Post
As about a dozen posters are about to inform you, those "hazards" are not as well supported by evidence as you may suppose
That's only because not many studies have been done on strictly thimerosal. But the main ingredient, mercury, has been tested plenty. When you add mercury with other ingredients in thimerosal it doesn't magically make mercury safe.
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Old 27th October 2009, 02:05 PM   #70
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Originally Posted by Eddie Dane View Post


That is disturbing. What is wrong with modern societies to have such strong anti-rational trends?
Because rationality is never that deep.There will never be a final victory over woo, given how human nature is go prone to it.
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Old 27th October 2009, 02:06 PM   #71
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Originally Posted by Without Rights View Post
That definitely is a "NO BRAIN-er"

H1N1 vaccine contains thimerosal which is well documented has being toxic and hazardous, especially to children.
You forgot to mention that vaccines contain water which is also well-documented as being toxic and hazardous, especially to children.

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Dr. Jefferson's requests for placebo-controlled studies on the effectiveness of flu vaccine have been called "radical" by the CDC.

When did it become radical to test effectiveness of a drug?
Exactly. This should be a big clue to you that the article you read grossly misrepresents the state of affairs.

There have also been a total of five links to articles written by people who know what they are talking about, rather than non-expert reporters, just a few posts up in this thread. Consider reading them.

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Person experience, I have never received a flu shot in my life and I only had the flu once in my 35 years.
Yeah, I haven't ever needed my seatbelt.

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Last edited by fls; 27th October 2009 at 02:07 PM.
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Old 27th October 2009, 02:06 PM   #72
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Originally Posted by BenBurch View Post
WR, nonsense like that is KILLING people. How can you be so smug and irresponsible?
Nice argument technique, but i need clarification.

What specifically is "nonsense"
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Old 27th October 2009, 02:10 PM   #73
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Originally Posted by BenBurch View Post
WR, nonsense like that is KILLING people. How can you be so smug and irresponsible?
Which is why I get upset when some "rational thinkers" try to let Bill Maher off the hook for his Anti Vax /Anti Modern Medicine rants (which are becoming a mainstay of his show) just becuase he says nasty things about organized religon.
Just because you reject organized religon does not mean you are a rational thinker. There are other forms of woo you can still fall for bigtime. And Maher has fallen for perhaps the most dangerous of them all. I get very tired of him being lionized by people who should really know better.

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Old 27th October 2009, 02:13 PM   #74
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Originally Posted by fls View Post
You forgot to mention that vaccines contain water which is also well-documented as being toxic and hazardous, especially to children.
No it hasn't



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Exactly. This should be a big clue to you that the article you read grossly misrepresents the state of affairs.
So the fact the CDC doesn't want to test effectiveness means I should trust them that it is effective? Interesting

Quote:
There have also been a total of five links to articles written by people who know what they are talking about, rather than non-expert reporters, just a few posts up in this thread. Consider reading them.
Dr. Tom Jefferson, head of the Vaccines Field at the Cochrane Collaboration, a highly respected international network of researchers who appraise medical evidence. Not a non-expert reporter.



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Yeah, I haven't ever needed my seatbelt.

Because car accidents and airborne viruses are the same.
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Old 27th October 2009, 02:15 PM   #75
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Originally Posted by dudalb View Post
Which is why I get upset when some "rational thinkers" try to let Bill Maher off the hook for his Anti Vax /Anti Modern Medicine rants
Off the hook?

Are you suggesting Bill Maher get in trouble for being anti vax, as you call it.
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Old 27th October 2009, 02:20 PM   #76
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Originally Posted by dudalb View Post
Because rationality is never that deep.There will never be a final victory over woo, given how human nature is go prone to it.
I do wonder though if there will be some disease in the future, with a pretty risk free and readily available vaccine, that will quite simply wipe out the anti-vaxxers.
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Old 27th October 2009, 02:20 PM   #77
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Originally Posted by dudalb View Post
And Maher has fallen for perhaps the most dangerous of them all.
So being against vaccination is dangerous and kills people. Debate over. Wow, I need some real world evidence on that one. Maybe a fact or two would help. Any idiot can say that about anything, where is your facts.
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Old 27th October 2009, 02:23 PM   #78
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Originally Posted by Puppycow View Post
To me, it seems very straightforward.
Somebody please feel free to correct me if my facts are wrong here, but over 5000 people have died so far of this strain of H1N1, and zero have died of the vaccine AFAIK, and zero have had negative reactions attributable to the vaccine AFAIK.

Not getting the vaccine is like playing Russian roulette.
Think of it as evolution in action
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Old 27th October 2009, 02:24 PM   #79
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Originally Posted by sackett View Post
Hey, Skept? Joe?

I prefer letting the pros do their job. Over a fairly long life (and it's nowhere near as long as I expect, given my experience with scientific medicine) I've learned to take doctor's orders.

Especially when they make sense that even a halfway intelligent layman can understand.
But if your doctor spews out nonsense that contradicts what the CDC and WHO are saying about the flu vaccine, I do not recommend following his advice.

That's why I objected to your advice to follow your doctor's advice no matter what.

(And there's another thread on this forum that describes a doctor whose advice was this sort of nonsense. So it does happen.)
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Old 27th October 2009, 02:25 PM   #80
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Originally Posted by softstuff View Post
I do wonder though if there will be some disease in the future, with a pretty risk free and readily available vaccine, that will quite simply wipe out the anti-vaxxers.
Not as long as they contain mercury, aluminum, hydrochloric acid, and formaldehyde
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