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#1 |
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Hot Tub Hottie
Join Date: Jul 2004
Location: Somewhere on the 3rd Meridian
Posts: 540
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BSM or Rolf - have you heard/read about these heartworm cures? 20 dogs supposedly cured, what happens when then next 20 are not? Will that be reported? Very sketchy "evidence". It bothers me that some gullible owners will resort to these "treatments". This post came into my mailbox this morning:
"Heartworm - Alternative Treatment The standard treatment for heartworm (intravenous arsenic) hasn't changed much in the last half of this century. Before I get into a recent development that shows great promise, I should mention that back in March 1993 an article in "Veterinary Forum" pointed out that studies from Cornell University and the University of Pennsylvania indicated that when Ivermectir or Milbemycin were given to heartworm positive dogs at the regular preventive dose, progressive microfilaria suppression was demonstrated. After approximately seven to eight months, most dogs were free of circulating microfilaria. Milbemycin appears to interfere with heartworm embryogeneses, and Ivermectin also has a suppressive effect on nematode reproduction. Thus the use of these drugs can be considered as an alternative modality for treatment. Evidently this form of treatment is an "extra-label use" and an informed consent should be signed by an owner before embarking upon this course. How many vets have ever mentioned this alternative? Now for the exciting news! An all-breed rescue club in Florida has been getting astounding results in treating heartworm cases with a homeopathic detoxsode for parasites called "Paratox". Please understand that these are "rescue" dogs that were in pretty sad condition when brought to them. For example, there was a German Shepherd that was so infested with heartworm that the attending vet commented that it was the worst case he had ever seen without the dog being dead! In this particular case, they did a 5 day course of "Clearing" (another homeopathic remedy made by the same company) prior to the Paratox treatment. When the dog was rechecked in 6 weeks, the infestation was deemed to be "very light". They repeated the Paratox treatment and subsequent testing showed the dog to be "clear"! So far, they have treated about 20 cases with 100% success! Evidently they can see a physical change in 2 weeks - better color, more vitality, etc. Another nice thing about this method is that they don't have to restrict the animals during treatment. The treatment is both gentle and simple, easy to administer and no side effects! In general, for dogs over 25 lbs, 5cc of Paratox is given orally, once a day for 24 days. One 40 oz bottle supplies a complete treatment. For smaller dogs, they have been using 2cc per day for 24 days. For giant breeds and severely compromised dogs they have been using double the usual daily dose(ie 10cc for 24 days). What about cost? I'm not sure if you are aware that the standard "arsenic" treatment can run well over $1,000.00. The alternative of using Ivermectin or Milbemycin is suggested to be for people that suffer from a "thin wallet". I'm sure you all know the cost of these drugs. Cost of one bottle of Paratox? Are you ready for this : $18.00!! How effective is it? As you are probably aware, the "snap" test currently being used to detect heartworm, registers titer levels and is sensitive enough to detect the presence of even one microfilaria or one worm. After one Paratox treatment, titers begin to drop in a very short time and within 3 to 4 months, usually register negative. By the way, I should mention that the results of the "snap" test should be read within 6 to 8 minutes for a true result. Otherwise the test will show a false "positive" reading. I now feel greatly relieved to know that I can use the heartworm nosode for prevention and in the rare event that it doesn't provide the needed protection, I certainly wouldn't hesitate to use Paratox as a safe, cost effective, treatment. Thank you, thank you, Florida Rescue for this wonderful "breeder network" information. Site listing alternative heartworm cures http://www.danebytes.com/heartworm-cures.htm (end of post) ******* Deb |
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#2 |
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Anti-homeopathy illuminati member
Join Date: Feb 2004
Location: Outside a banana and far from a razor
Posts: 5,262
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No idea, other than to state the obvious that if it is really an over-diluted homeopathic remedy then it is more likely that the story is not quite what it seems, but I'd need to read some properly validated evidence.
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"i'm frankly surprised homeopathy does as well as placebo" Anonymous homeopath. "Alas, to wear the mantle of Galileo it is not enough that you be persecuted by an unkind establishment; you must also be right." (Robert Park) Is the pen is mightier than the sword? Its effectiveness as a weapon is certainly enhanced if it is sharpened properly and poked in the eye of your opponent. |
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#3 |
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Anti-homeopathy illuminati member
Join Date: Sep 2003
Location: NT 150 511
Posts: 34,312
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Since Dirofilaria immitis infection doesn't happen in this country, it's not something I'm terribly well up on. However, I do know they're wrong about the "arsenic". I've seen advertisements for drugs licensed to treat heartworm, such as "Advocate", and they don't contain arsenic.
I'd give this one about ten minutes to appear on a mainly-US alternative veterinary medicine email group I'm on, and about another fifteen to be thoroughly and totally shredded. Rolfe. |
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"The way we vote will depend, ultimately, on whether we are persuaded to hope or to fear." - Aonghas MacNeacail, June 2012. |
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#4 |
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Hot Tub Hottie
Join Date: Jul 2004
Location: Somewhere on the 3rd Meridian
Posts: 540
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Keeper of the Secret Stuff. |
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#5 |
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Anti-homeopathy illuminati member
Join Date: Sep 2003
Location: NT 150 511
Posts: 34,312
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"The way we vote will depend, ultimately, on whether we are persuaded to hope or to fear." - Aonghas MacNeacail, June 2012. |
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#6 |
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Lackey
Administrator / JREF Forum Liaison
Join Date: Aug 2001
Location: South East, UK
Posts: 64,732
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6 months to treat heartworm - isn't that a long time?
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If it were all so simple! If only there were evil people somewhere insidiously committing evil deeds, and it were necessary only to separate them from the rest of us and destroy them. But the line dividing good and evil cuts through the heart of every human being. And who is willing to destroy a piece of his own heart? - Aleksandr Solzhenitsyn 1918-2008
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#7 |
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Anti-homeopathy illuminati member
Join Date: Sep 2003
Location: NT 150 511
Posts: 34,312
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You better get John Bentley and Dogdoctor in here. Us Brits have no practical experience with the condition. (Dogdoctor is on the email list I mentioned too, we'll see if anyone there has any comments.)
Rolfe. |
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"The way we vote will depend, ultimately, on whether we are persuaded to hope or to fear." - Aonghas MacNeacail, June 2012. |
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#8 |
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Critical Thinker
Join Date: Apr 2004
Posts: 454
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Hi. Sorry I got here late. Been replying to BSM on the PM, and waiting until I calm down before I replied.
First, a short primer on heartworm disease for Brits: 1. Heartworm disease is caused by gruesome parasites, anywhere from 3 to 6 inches long (8 to 15 cm), that live in the right ventricle of the heart, with some extension into the main pulmonary arteries, and vena cava. These parasites are transmitted to the dog from mosquito bites. The mosquito bites an infected dog, sucks up some microfilaria (microscopic larva stage) from the bloodstream, the microfilaria undergo a change inside the mosquito gut into an infective larval stage, and when the mosquito bites another dog, the infective larvae are injected into the next dog. The mosquito is a necessary stage of the life cycle. Even if you gave an uninfected dog a blood transfusion full of microfilaria laden blood from an infected dog, the parasite would not be transmitted, because it didn't go through the mosquito first. Ain't parasitology grand! 2. The symptoms of the disease are heart failure, kidney failure, liver failure, primary pulmonary hypertension, and/or sudden death from lung embolisms. It can take years for an infected dog to show symptoms. All symptoms are caused only by adult heartworms, not by microfilaria or larval stages. 3. The test for heartworms mentioned in the OP tests for adult heartworm antigens circulating in the bloodstream. 4. Treating a dog with ivermectin or milbemycin, as mentioned in the OP, may kill off the microfilaria, but may not kill the adult heartworms. It may make the adult heartworms sterile, so the dog may not produce any microfilaria. So What! The dog probably still has adult heartworms, which are the only form that causes disease. Adult heartworms will die after 5 years or so. Ivermectin hastens that death, so they may die in 2 years. Even so, the dog has adult heartworms for 2 years. The damage done to the heart, lungs, and kidneys is permanent. So for 2 years, the dog is undergoing irreparable damage. And it only clears the adult heartworms in about 75% of the dogs. Very bad alternative to Immiticide. 5. Immiticide is technically an arsenical, but only to a chemist. It is pretty non-toxic to the dog. It is not given IV, but in the back muscles. It is expensive because it is the only approved drug on the market, and it is still under patent. The patent runs out in a couple of years, I think, at which time, the price will plummet. 6. Looking at the web sites for Paratox, I must say it is unadulterated BS. I am trying to find out which, if any, veterinarians are recommending this claptrap, and sending their names into the Florida Veterinary Board. That will probably do nothing, but it will make me feel better. |
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#9 |
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Anti-homeopathy illuminati member
Join Date: Sep 2003
Location: NT 150 511
Posts: 34,312
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Thanks. Very similar messages now coming up on AltVetSkept. If I knew what was in "Advocate" (apparently licensed for heartworm here, but possibly only as preventative I don't know), I'd ask you about it.
Tomorrow. What are these people thinking of? Where are they getting their so-called data? Rolfe. |
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"The way we vote will depend, ultimately, on whether we are persuaded to hope or to fear." - Aonghas MacNeacail, June 2012. |
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#10 |
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Copper Alloy Canid
Join Date: Mar 2005
Location: Homebrew D&D Campaign Setting
Posts: 5,007
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Given the information on what those worms do to the dogs in item number 4, and the the thought that many people are probably "treating" it with quackery like homeopathy... I think I've hit a new, higher plateau in my quiet rage against nonsense.
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Stop Sylvia Browne Warning: Beware of contaminated water supplies! Suspected source of contamination: Sarah-I A non-Rockstar Rambler and dissector of Doggerel |
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#11 |
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Banned
Join Date: Sep 2002
Posts: 26,985
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Heartworm is common in tropical Australia. Most dogs there are medicated to prevent infections. I can't remember the name of the substance, but we used to give our dog "a pill" every day to prevent heartworm attack. That was 30 years ago, and I understand now they have either a monthly pill, or some form of vaccine.
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#12 |
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Anti-homeopathy illuminati member
Join Date: Feb 2004
Location: Outside a banana and far from a razor
Posts: 5,262
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Deb
I think I'd like to see some proper detail on the allegedly successful trial. It so defies belief that I can almost guarantee that it is not what it seems, but I'd need more precise information first. |
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"i'm frankly surprised homeopathy does as well as placebo" Anonymous homeopath. "Alas, to wear the mantle of Galileo it is not enough that you be persecuted by an unkind establishment; you must also be right." (Robert Park) Is the pen is mightier than the sword? Its effectiveness as a weapon is certainly enhanced if it is sharpened properly and poked in the eye of your opponent. |
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#13 |
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Vortex of Despair
Join Date: Oct 2005
Location: Sheep country, Eastern Oz
Posts: 1,585
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Yes, all correct. There is a monthly dose and, I believe, 6 monthly injections. (Not 101% certain this bit).
I was talking to my vet the other day about this and he said that in my area, southern tablelands NSW, there isn't much of it around and he hasn't seen any cases at all in his current practice. |
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"It's not that sicence doesn't agree so I ignore it, it's that I know what science knows, but also what is beyond science, so therefore, I also know when it is wrong" - Kilik - |
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#14 |
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Hot Tub Hottie
Join Date: Jul 2004
Location: Somewhere on the 3rd Meridian
Posts: 540
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__________________
Keeper of the Secret Stuff. |
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#15 |
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Hot Tub Hottie
Join Date: Jul 2004
Location: Somewhere on the 3rd Meridian
Posts: 540
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__________________
Keeper of the Secret Stuff. |
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#16 |
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Critical Thinker
Join Date: Apr 2004
Posts: 454
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Current preventatives are:
1. Low dose ivermectin - given orally once a month. It kills all larval stages that can develop in 1 month's time. 2. Low dose milbemycin - same as above. Has the advantage of also killing the three common intestinal worms, i.e. hookworms, roundworms, and whipworms. 3. Selamectin - sold as Revolution (TM). Applied topically to the skin once a month. It is absorbed through the skin and enters the bloodstream, killing all larval stages than can develop in a month's time. Has the advantage of also killing about 80% of roundworms and hookworms, and redistributes to the sebaceous glands in the skin. When it comes out onto the skin with the skin oil, it kills fleas, ticks, mange mites, and ear mites. Really good product, but has had some breaks reported in it's heartworm prevention, with some dogs who were using the product coming up heartworm positive. Probably has to do with the fact that it is topically applied. If all of it is not absorbed properly, there's not enough in the bloodstream to do the job. I mainly use it for treating mange, fleas, and ear mites. 4. ProHeart(TM) (Moxidectin) - injected under the skin once every six months. It is a slow release pesticide that had been used in horses and cattle for years. Was recalled by the FDA in 2004 after several hundred deaths and thousands of adverse reactions were reported in dogs, including seizures, vomiting, diarrhea, liver failure. No longer available. There is currently no vaccine available, although the big drug companies have been telling us it is "on the horizon" for several years now. All I can say is their horizon is certainly further away than mine. Possibly they are all on a different planet. ETA: I don't think the daily preventative is available any more. It was called Filaribits, and if you missed a single dose, the dog was unprotected. Also, the product was reported to cause liver problems in a small percentage of dogs. |
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#17 |
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Critical Thinker
Join Date: Apr 2004
Posts: 454
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I just noticed that the site quoted by Debaroo gives an FDA registration number for the supposed product. Specifically: FDA Registration No. 2937060. Does anyone know how to track down what was submitted to the FDA (That's Food and Drug Administration for you furriners), in order to get that product registered? That would at least tell us if it is registered as a drug (which requires extensive testing and proof of efficacy before being sold in the US), or as a "food supplement" (which requires no testing or proof of efficacy or any d*mn thing at all to be sold in the US).
ETA: If sold as a food supplement, then they are technically breaking the law by claiming a specific medicinal effect: i.e. heartworm treatment. The FDA gets really touchy about that, so I'd really like to know how to track down that registration number. |
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#18 |
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Graduate Poster
Join Date: Jan 2003
Location: Decatur, Illinois, USA
Posts: 1,453
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That's a food facility registration number from the FDA. It's to "protect the food supply from bioterrorism".
http://www.cfsan.fda.gov/~dms/fsbtac12.html
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#19 |
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Graduate Poster
Join Date: Jan 2003
Location: Decatur, Illinois, USA
Posts: 1,453
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Quote:
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They're covered. All the claims are being made by the purveyors, not the manufacturer. The FDA can't touch the manufacturer. |
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#20 |
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Critical Thinker
Join Date: Apr 2004
Posts: 454
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Actually, I really wasn't thinking about going after the manufacturer, just the purveyors, especially if they are veterinarians. However, after re-reading the web site as you suggested, I find that no vets are specifically listed. Unless Dr. Wessner in FL is one. I'll have to check that out.
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#21 |
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Graduate Poster
Join Date: Jan 2003
Location: Decatur, Illinois, USA
Posts: 1,453
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The trouble is, the FDA and the FTC aren't really interested in going after every individual purveyor who promises that the product he's selling will cure something. Look at all the folks on the Internet who makes claims for things like saw palmetto and ginseng; they never get prosecuted.
Googling around...Dr. Gerald Wessner is a homeopathic vet, with the Holistic Veterinary Clinic in Summerfield, Florida. As he's already a homeopath, I doubt whether any "do you realize what you're selling?" letters would have any effect. Yes, he certainly does know what he's purveying, and what's more, since it comes under the heading of "alternative medicine" and since he's not claiming flat-out that Protox can cure heartworms, legally he's copacetic. |
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#22 |
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Anti-homeopathy illuminati member
Join Date: Sep 2003
Location: NT 150 511
Posts: 34,312
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Woo vets are a big problem. Tell me about it!
Just one extra comment from the email list.
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Rolfe. |
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"The way we vote will depend, ultimately, on whether we are persuaded to hope or to fear." - Aonghas MacNeacail, June 2012. |
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#23 |
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Critical Thinker
Join Date: Apr 2004
Posts: 454
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Rolfe,
Fort Dodge (the manufacturer of the moxidectin product over here) is making noises about bringing ProHeart back on the market. I have some problems with Fort Dodge anyway. They have a history of rushing unsafe or unproven products to the veterinary market, and then having to recall them. As far as safety with moxidectin, I'm pretty sure that it was not the route of entry (injection vs. spot-on) that was involved, but rather the amount of material deposited. I assume that Advocate is a once-a-month product, whereas Proheart was an injection that was supposed to last 6 months as a slow release bolus. I suspect that it didn't release quite as slowly as expected in some animals, thus causing overdosages. I would be very interested in the claims for Advocate in treating demodectic mange. We have very few treatment modalities over here for that problem. Finally, there are many examples of veterinary pharmaceuticals approved and used on the European continent, England, and Canada for years before gaining FDA approval in the US. So does this mean that the FDA is more stringent than the equivalent agency in those other countries, or just protectionist? I don't know, but I would bet that Advocate is safe as a once-a-month product. I can tell you that it isn't marketed over here. I've never heard of it, and if it treats demodectic mange, there would be a big market for it here. |
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#24 |
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Anti-homeopathy illuminati member
Join Date: Sep 2003
Location: NT 150 511
Posts: 34,312
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I asked Badly Shaved Monkey about this, and he said he'd only had a rep visiting him and claiming 80% success against demodex. (Your thought was mine - when I saw the demodex claim, I thought this could be great.) I wasn't that impressed with the 80% claim because we've all heard that before, but since then I've talked to a colleague who has actually used it in a handful of demodex cases, and he was really quite impressed.
I know, we've been there before, and it will take some time and clinical experience before we really know how it performs in clinical situations in the field, but at the moment I'm cautiously optimistic. Someone has stolen my 2005 Compendium of Data Sheets so I can't check the details of dosage regimen right now. By the way, do you really not have trilostane yet? It's the greatest! Rolfe. |
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"The way we vote will depend, ultimately, on whether we are persuaded to hope or to fear." - Aonghas MacNeacail, June 2012. |
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#25 |
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Critical Thinker
Join Date: Apr 2004
Posts: 454
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Yeah, those jerks.
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Hmmm....How vindictive can I be? Maybe I can start a stink in Florida like Rolfe's trying to do on her side of the pond. Force the Florida Veterinary Board to actually grow a spine and take a stand on the subject of alternative therapy in veterinary medicine. Couple of problems with that: 1. I'm not licensed in the state of Florida, so they probably won't care what I think. 2. The Florida School of Veterinary Medicine is already teaching raving woo. Here's the course description: (VEM 5208 Additional Approaches to Disease Prevention and Treatment - 1 credit. Additional approaches to alternative medicine to disease prevention and treatment by humans, owners of companion animals and veterinarians about the use of these modalities in animals. Course Coordinator - Dr. R. Clemmons; Grading System - Letter grade. ) I think we can assume that the Florida Veterinary Board has already decided to bend over and take it on this one, or surely they would not be giving accreditation to the school while they teach this crap. At least it only gets 1 credit. No info as to whether it is a required course or not. |
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#26 |
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Anti-homeopathy illuminati member
Join Date: Sep 2003
Location: NT 150 511
Posts: 34,312
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Is that the "fuller and better particulars" of what I was talking about in this post?
http://206.225.95.123/forumlive/show...72#post1278672 Rolfe. |
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"The way we vote will depend, ultimately, on whether we are persuaded to hope or to fear." - Aonghas MacNeacail, June 2012. |
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#27 |
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Critical Thinker
Join Date: Apr 2004
Posts: 454
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Just out of curiosity, I Googled Dr. R. Clemmons, the course coordinator for the woo course taught at Florida's Veterinary School.
He seems well lettered, and has tenure there, has received many awards, etc. Lists Alternative Medicine as one of his research interests. Now here is the funny part. Out of over 50 publications in journals and textbooks, not a single one involves alternative medicine. Gee, I wonder why he hasn't gotten any of those published? |
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#28 |
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Critical Thinker
Join Date: Apr 2004
Posts: 454
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#29 |
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Graduate Poster
Join Date: Jan 2003
Location: Decatur, Illinois, USA
Posts: 1,453
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Well, my son is in his first year of Pre-Veterinary, and in defense of the Florida SVM, I can see the point in their VEM 5208 course: it's not so much a course in "how to treat animals with alternative woo" as it is a course in "here's the alternative woo that's out there, so when the owners come in and ask you about it, you'll know what they're talking about."
Companion Animals is VERY big business in his coursework. You gotta deal with Flopsy's Mommy before you can deal with Flopsy... It's only a 1 semester course, right? And it's only 1 credit, so that's really just "filler", a sort of "oh, by the way..." course. If they really meant to train vets how to apply woo to animals, it would occupy a bigger chunk of the curriculum.
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#30 |
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Critical Thinker
Join Date: Apr 2004
Posts: 454
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You have truly made me feel a lot better, if what you say is true. However, there is this reference I found on a Google search. http://72.14.203.104/search?q=cache:...mmons%22&hl=en
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#31 |
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Anti-homeopathy illuminati member
Join Date: Sep 2003
Location: NT 150 511
Posts: 34,312
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Well, I don't know anything first-hand, but I have heard that Gainsville has a terrible reputation for propagating woo. Some Merikan vets have been seen
![]() over it all. With many more stories like John's, above. Rolfe. |
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"The way we vote will depend, ultimately, on whether we are persuaded to hope or to fear." - Aonghas MacNeacail, June 2012. |
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